Etiology of Caudal Regression Syndrome
نویسندگان
چکیده
منابع مشابه
Etiology of Caudal Regression SyndromeY
Caudal regression syndrome (CRS) is a rare congenital disorder in which lumbosacral anomalies are combined with anorectal and urogenital malformations. However, the molecular mechanisms of human CRS are not yet known. Trauma, nutritional problems, toxic agents, and genetics are suggested in the etiology of CRS. To the best of our knowledge, linkage studies of families affected exclusively by CR...
متن کاملCaudal Regression Syndrome
Caudal regression syndrome (CRS) is a rare neural tube defect affecting terminal spinal segments and cord manifesting as neurological deficit ranging from bladder and bowel involvement to severe sensory motor deficits in lower limbs. It has sporadic appearance and maternal diabetes, genetic factors, teratogens and hypoperfusion are considered as possible etiologic factors and it can be associat...
متن کاملCaudal regression syndrome.
INTRODUCTION The regression caudal syndrome includes a spectrum of malformations which vary from the symptomless coccygeal agenesis until thoracic vertebrae and sacrococcygeal agenesis with severe neurological deficit; it is associated sometimes with malformations in other organs and systems. We present a case of partial agenesis of sacro and coccix with neuromuscular, sphincter and orthopedist...
متن کاملPrenatal diagnosed caudal regression syndrome
Background: Caudal regression syndrome (CRS) is a rare complex congenital anomaly which is characterized by agenesis of the sacral and lumbar spine. Pelvis, lower extremity, genitourinary, cardiac anomalies and lower extremity neurological and motor development deficits may be accompanied. The exact etiology is unclear but the maternal insulin-dependent diabetes mellitus (hyperglycaemia during ...
متن کاملIn utero diagnosis of caudal regression syndrome
We present a case of caudal regression syndrome (CRS), a relatively uncommon defect of the lower spine accompanied by a wide range of developmental abnormalities. CRS is closely associated with pregestational diabetes and is nearly 200 times more prevalent in infants of diabetic mothers (1, 2). We report a case of prenatally suspected CRS in a fetus of a nondiabetic mother and discuss how the i...
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ژورنال
عنوان ژورنال: Human Genetics & Embryology
سال: 2013
ISSN: 2161-0436
DOI: 10.4172/2161-0436.1000107